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Article

Characterizing non-hallucinogenic psychedelics beyond the head twitch response: phenotypic fingerprinting of lisuride and LSD.

Translational psychiatry - 13 Jun 2026

King Jillian L, Effinger Devin P, Basquez-Pfeifer Cameron, Wallingford Janae R, Calderon Joselynn R, O'Connell Caden K, Thompson Scott M

Abstract excerpt

The head-twitch response (HTR) is widely used as a preclinical assay for the hallucinogenic potential of compounds, with its utility based on 5HT2AR activation. Here, we examine how the polypharmacological agonists lisuride and lysergic acid diethylamide (LSD) influence behavioral and physiological outcomes in mice to test whether the HTR reliably reflects overall psychoactivity. Lisuride (0.5 mg/kg) elicited no...

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Identifiers

PMID: 42288474
DOI: 10.1038/s41398-026-04174-4
PMCID: PMC13490424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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