Article
Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors.
Neuroscience - 1 Jan 2000
Chen J F, Beilstein M, Xu Y H, Turner T J, Moratalla R, Standaert D G, Aloyo V J, Fink J S, Schwarzschild M A
Abstract excerpt
A(2A) adenosine receptors are highly expressed in the striatum where they modulate dopaminergic activity. The role of A(2A) receptors in psychostimulant action is less well understood because of the lack of A(2A)-selective compounds with access to the central nervous system. To investigate the A(2A) adenosinergic regulation of psychostimulant responses, we examined the consequences of genetic deletion of A(2A)...
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