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Article

Role of hippocampal 5-HT1A receptors in the antidepressant-like phenotype of mice expressing RGS-insensitive Gαi2 protein.

Neuropharmacology - 1 Oct 2018

Senese Nicolas B, Oginsky Max, Neubig Richard R, Ferrario Carrie, Jutkiewicz Emily M, Traynor John R

Abstract excerpt

A single base mutation in the Gαi2 protein (G184S) renders this Gα subunit insensitive to the negative modulatory effects of Regulator of G-protein Signaling (RGS) proteins. Mice expressing this RGS insensitive (RGSi) variant of Gαi2 (RGSi Gαi2) display a spontaneous antidepressant-like phenotype that is reversible by treatment with the 5-HT1A receptor (5-HT1AR) antagonist WAY100635. Here we test the hypothesis...

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Identifiers

PMID: 30189184
DOI: 10.1016/j.neuropharm.2018.09.002
PMCID: PMC6392198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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