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Article

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2016

Marchant Nathan J, Whitaker Leslie R, Bossert Jennifer M, Harvey Brandon K, Hope Bruce T, Kaganovsky Konstantin, Adhikary Sweta, Prisinzano Thomas E, Vardy Eyal, Roth Bryan L, Shaham Yavin

Abstract excerpt

In the past decade, novel methods using engineered receptors have enabled researchers to manipulate neuronal activity with increased spatial and temporal specificity. One widely used chemogenetic method in mice and rats is the DREADD (designer receptors exclusively activated by designer drugs) system in which a mutated muscarinic G protein-coupled receptor is activated by an otherwise inert synthetic ligand,...

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Identifiers

PMID: 26019014
DOI: 10.1038/npp.2015.149
PMCID: PMC5130116

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