Article

Transcriptomic - metabolomic integration reveals baicalein delays astrocyte senescence by modulating fumaric acid and oxoglutaric acid metabolism

2025-05-07

Abstract excerpt

<h4>Background: </h4> and Purpose: Astrocyte senescence plays a critical role in age-related cognitive decline and Alzheimer’s disease. This study investigated whether baicalein can delay astrocyte senescence and alleviate age-related cognitive decline. Meanwhile we explored the potential mechanisms by focusing on alterations in lipid metabolism. Experimental Approach: The anti-astrocyte senescence effects of baic...

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Literature Corpus work: dd50e72c-5784-546d-9c10-fe840e461318
DOI: 10.22541/au.174662173.38467512/v1

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