Article

The novel target, mechanism and agonist of α-Ketoglutaric acid in delaying mesenchymal stem cell senescence

2024-09-25

Abstract excerpt

<title>Abstract</title> <p>α-Ketoglutaric acid (aKG) participates in the tricarboxylic acid cycle in the process of cell aerobic metabolism and is of significant physiological importance. Although aKG is genetically associated with human longevity and decreased fertility, its anti-aging mechanism remain largely unknown. Here, we used interdisciplinary techniques such as metabolomics, chemical biology, and organoi...

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Literature Corpus work: 23701112-b72e-5668-806e-18adc287fa4d
DOI: 10.21203/rs.3.rs-5000966/v1

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