Article
Senescent Phenotype of Astrocytes Leads to Activation of BV2 Microglia and N2a Neuronal Cells Death.
Molecules (Basel, Switzerland) - 12 Sept 2022
Zhang Wenyou, Yang Xuehan, Liu Jingyue, Pan Yichen, Zhang Ming, Chen Li
Abstract excerpt
(1) Background: Astrocytes, the most abundant cell type in the central nervous system, are essential to tune individual-to-network neuronal activity. Senescence in astrocytes has been discovered as a crucial contributor to several age-related neurological diseases. Here, we aim to observe if astrocytes demonstrate senescence in the process of brain aging, and whether they bring adverse factors, especially harm to...
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