Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta

Abstract excerpt

AD pathology is accompanied by increased senescence and reduced levels of autophagy in the brain. We investigated whether pharmacologically inducing autophagy could alter the senescent phenotype and help ameliorate AD pathology. We discovered that Bisdemethoxycurcumin (BDMC), a natural compound found in Curcuma longa , stimulates autophagy in primary astrocytes. We found that autophagy and senescence exhibit an i...

Topics

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• Alzheimer's disease research and treatments
• Autophagy in Disease and Therapy
• Curcumin's Biomedical Applications
• Genomics, phytochemicals, and oxidative stress
• MicroRNA in disease regulation
• Neuroinflammation and Neurodegeneration Mechanisms
• Sirtuins and Resveratrol in Medicine
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

85c1777b-f416-59af-8588-1a21632c07fb

DOI

10.1101/2025.05.19.654834