Article

Astrocyte senescence in an Alzheimer’s disease mouse model is mediated by TGF-β1 and results in neurotoxicity

2019-07-12

Abstract excerpt

<h4>ABSTRACT</h4> Alterations in astrocyte function such as a pro-inflammatory phenotype are associated with Alzheimer’s disease (AD). We had shown impairments in the ability of aged astrocytes isolated from 5xFAD mice to clear and uptake amyloid-β (Aβ) as well as to support neuronal growth. Senescent cells accumulate with age and exhibit a senescence-associated secretory phenotype, which includes secretion of pr...

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Literature Corpus work: 2d5a02f0-1b6e-5313-ae3b-afa6abe58091
DOI: 10.1101/700013

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