Article

Characterizing the metabolomes of microglia, astrocytes, and neurons in aging and Alzheimer’s brains

2026-02-06

Abstract excerpt

Neurons and glia are distinct in their morphology, development, and function, possessing unique transcriptomes and proteomes, but little is known about their metabolomes. The challenge of brain cell metabolic profiling is to obtain a large number of cells for reliable analysis. Here, we purified microglia, astrocytes, and neurons from mouse brains, identifying >70 metabolites through targeted metabolomics and 9,85...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93e8c167-1b3c-5522-be91-f539b76d2a49
DOI: 10.64898/2026.02.06.703980

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterizing the metabolomes of microglia, astrocytes, and neurons in aging and Alzheimer’s brainsDOI 10.64898/2026.02.06.703980Read

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brainSemantic proximity Read

The role of microglia immunometabolism in neurodegeneration: Focus on molecular determinants and metabolic intermediates of metabolic reprogrammingSemantic proximity Read

Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's diseaseSemantic proximity Read

Multi-omics analysis reveals neuroinflammation, activated glial signaling, and dysregulated synaptic signaling and metabolism in the hippocampus of aged miceSemantic proximity Read

Metabolic Profiling and Phenotyping of Central Nervous System Diseases: Metabolites Bring Insights into Brain Dysfunctions.Semantic proximity Read

Cell type-specific master metabolic regulators of Alzheimer’s diseaseSemantic proximity Read

Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer’s diseaseSemantic proximity Read

Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system.Semantic proximity Read

A Multi-Organ Murine Metabolomics Atlas Reveals Molecular Dysregulations in Alzheimer’s DiseaseSemantic proximity Read

Identifying neuron subtype-specific metabolic network changes in single cell transcriptomics of Alzheimer’s Disease using perturb-MetSemantic proximity Read

Multi-omics reveals changes in astrocyte fatty acid metabolism during early stages of Alzheimer's diseaseSemantic proximity Read

Exploring the key role of neuroinflammation in the formation of delayed encephalopathy after acute carbon monoxide poisoning based on multi-omics and snRNA-seqSemantic proximity Read