The Senescent Phenotype of Cultured Hypothalamic Astrocytes from Rats with Streptozotocin-Induced Dementia.

doi:10.1007/s11064-026-04884-7

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The Senescent Phenotype of Cultured Hypothalamic Astrocytes from Rats with Streptozotocin-Induced Dementia.

Neurochemical research - 11 Sept 2026

Da Silva Vanessa-Fernanda, da Costa Daniele Schauren, Gayger-Dias Vitor, Sobottka Thomas Michel, Da Silva Ana Carolina Ribeiro, Biolchi Bruna Cristiana R, da Silva Laíse Freese, Zasso Nikoli, Weber Fernanda Becker, Schimitz Izaviany, Machado Diorlon Nunes, Netto Carlos Alexandre, Leite Marina Concli, Bobermin Larissa Daniele, Quincozes-Santos André, Gonçalves Carlos-Alberto

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent form of dementia, with aging as its primary risk factor. Among experimental models of sporadic AD, intracerebroventricular (ICV) administration of streptozotocin (STZ) in rodents is widely used. We hypothesized that STZ accelerates the process of cellular senescence, which in astrocytes can be assessed using classic markers, including p16, β-galactosidase, Lamin B1,...

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Topics

Animals
Astrocytes
Male
Streptozocin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Rats, Wistar

Cells, Cultured

Hypothalamus

Cellular Senescence

Dementia

Rats

S100 Calcium Binding Protein beta Subunit

Phenotype

Source

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Identifiers

PMID: 42726406
DOI: 10.1007/s11064-026-04884-7
PMCID: PMC13569601

Genes

S100B
HMGB1

Variants

Provenance

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