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Article

Allele-specific genome-wide profiling in human primary erythroblasts reveal replication program organization.

PLoS genetics - 1 May 2014

Mukhopadhyay Rituparna, Lajugie Julien, Fourel Nicolas, Selzer Ari, Schizas Michael, Bartholdy Boris, Mar Jessica, Lin Chii Mei, Martin Melvenia M, Ryan Michael, Aladjem Mirit I, Bouhassira Eric E

Abstract excerpt

We have developed a new approach to characterize allele-specific timing of DNA replication genome-wide in human primary basophilic erythroblasts. We show that the two chromosome homologs replicate at the same time in about 88% of the genome and that large structural variants are preferentially associated with asynchronous replication. We identified about 600 megabase-sized asynchronously replicated domains in two...

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Identifiers

PMID: 24787348
DOI: 10.1371/journal.pgen.1004319
PMCID: PMC4006724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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