Article

Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer’s disease

2023-04-29

Abstract excerpt

<h4>ABSTRACT</h4> Common features of Alzheimer’s disease (AD) include amyloid pathology, microglia activation and synaptic dysfunction, however, the causal relationships amongst them remains unclear. Further, human data suggest susceptibility and resilience to AD neuropathology is controlled by genetic context, a factor underexplored in mouse models. To this end, we leveraged viral strategies to label an AD-vulne...

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Literature Corpus work: dd20b739-971e-5ad4-897e-3211a904d57b
DOI: 10.1101/2023.04.28.538728

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