Article

Microglia determine ß-amyloid plaque burden but are non-essential for downstream pathology

2024-08-08

Abstract excerpt

Evidence points to a role for microglia in Alzheimer’s disease (AD) risk, although their position in the pathological cascade is incompletely understood, prompting us to generate a model of ß-amyloidopathy lacking microglia. We find evidence that microglia promote plaque formation and creation of an Aß fibril-rich zone surrounding the plaque core. However, plaque-proximal reactive astrogliosis, synapse loss, and n...

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Identifiers and source

Literature Corpus work: 296be287-c336-5aa8-914a-423ccb6d574a
DOI: 10.1101/2024.08.06.606795

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