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Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in <i>APP</i> <sub>Swe</sub> / <i>PSEN1</i> <sub>M146V</sub> transgenic mice

2018-09-17

Abstract excerpt

<h4>Background</h4> Progression of Alzheimer’s disease is thought initially to depend on rising amyloidβ and its synaptic interactions. Transgenic mice (TASTPM; APP Swe / PSEN1 M146V ) show altered synaptic transmission, compatible with increased physiological function of amyloidβ, before plaques are detected. Recently, the importance of microglia has become apparent in the human disease. Similarly, TASTPM show...

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Literature Corpus work
87a6eb89-4897-540f-9db4-1c6a1d3e840c
DOI
10.1101/420349
Open publication

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Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in <i>APP</i> <sub>Swe</sub> / <i>PSEN1</i> <sub>M146V</sub> transgenic miceDOI 10.1101/420349
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