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Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1α

2019-05-17

Abstract excerpt

<h4>ABSTRACT</h4> The important role of microglia, the brain’s resident immune cells, in Alzheimer’s disease (AD) is now well recognized, however their molecular and functional diversity and underlying mechanisms still remain controversial. To transcriptionally and functionally characterize the diversity of microglia in AD and aging, we isolated the amyloid plaque-containing (XO4 + ) and non-containing (XO4 − )...

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Literature Corpus work
8f541cc3-1746-5271-9ed4-d426df9a5909
DOI
10.1101/639054
Open publication

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