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Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia

15 Jul 2021

Abstract excerpt

BACKGROUND: Microglia are active modulators of Alzheimer's disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add novel findings concerning these relationships and investigate which of our previously reported results from transgenic mice can be validated in knock-in mice, in which overexpression and other artefacts of transgenic technology are...

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PMID: 34266459
DOI: 10.1186/s13024-021-00457-0

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