Article

Unmasking Early Microglial Remodeling in an Alzheimer’s Disease Mouse Model

2025-10-08

Abstract excerpt

Early neuroimmune remodeling is a critical yet understudied component of Alzheimer’s disease (AD) pathogenesis. To investigate microglial contributions to AD development prior to overt plaque deposition, we developed an open-source morphometric pipeline to systematically quantify hippocampal microglial structure and activation states in pre-plaque 5xFAD mice. Across ∼11,000 cells, we extracted multidimensional par...

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Identifiers and source

Literature Corpus work: 21079e61-0281-50f7-bc0e-be79cbea4951
DOI: 10.1101/2025.10.07.681006

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