Article

Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol

2022-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Neuroinflammation is a major hallmark of Alzheimer’s disease and several other neurological and psychiatric disorders and is often associated with dysregulated cholesterol metabolism. Relative to homeostatic microglia, activated microglia express higher levels of Ch25h , an enzyme that hydroxylates cholesterol to produce 25-hydroxycholesterol (25HC). 25HC is an oxysterol with interesting immune...

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Literature Corpus work: dcc0a9fc-f87b-597f-bdf7-e903866d687f
DOI: 10.1101/2022.05.03.490494

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