Article

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

2020-03-03

Abstract excerpt

<title>Abstract</title> <p>Background : Genome-wide association studies of Alzheimer’s disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology. However, the exact cellular and chemical mediators of neuroinflammation in AD remain poorly understood. The oxysterol 25-hydroxycholesterol (25-HC) is an important immunomodulator produced by peripheral macrophages with...

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Literature Corpus work: 223e968a-7c51-5450-8906-7d8507a1145e
DOI: 10.21203/rs.3.rs-15868/v1

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