Article

25-hydroxycholesterol mediates brain cytokine production and neutrophil infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation

2023-10-13

Abstract excerpt

<h4>ABSTRACT</h4> Neuroinflammation has been implicated in the pathogenesis of several neurologic and psychiatric disorders. Microglia are key drivers of neuroinflammation and in response to different inflammatory stimuli overexpress a proinflammatory signature of genes. Among these, Ch25h is a gene overexpressed in brain tissue from Alzheimer’s disease as well as various mouse models of neuroinflammation. Ch25...

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Literature Corpus work: 4d3158a0-ffbb-5cde-a590-a0d3ba5065fc
DOI: 10.1101/2023.10.09.561598

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