Article

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

2020-01-15

Abstract excerpt

Genome-wide association studies associated with Alzheimer’s disease (AD) have implicated pathways related to both lipid homeostasis and innate immunity in the pathophysiology of AD. However, the exact cellular and chemical mediators of neuroinflammation in AD remain poorly understood. The oxysterol 25-hydroxycholesterol (25-HC) is an important immunomodulator produced by peripheral macrophages with wide-ranging ef...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2d3470a7-840a-5d75-a5a0-f0c31b1544ea
DOI: 10.1101/2020.01.14.906966

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent mannerDOI 10.1101/2020.01.14.906966Read

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent mannerSemantic proximity Read

25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammationSemantic proximity Read

25-hydroxycholesterol mediates brain cytokine production and neutrophil infiltration in a mouse model of lipopolysaccharide-induced neuroinflammationSemantic proximity Read

Microglial 25-hydroxycholesterol mediates neuroinflammation and neurodegeneration in a tauopathy mouse modelSemantic proximity Read

Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterolSemantic proximity Read

Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia.Semantic proximity Read

APOE4 confers transcriptomic and functional alterations to primary mouse microglia.Semantic proximity Read

Integrated stress response associated with dark microglia promotes microglial lipogenesis and contributes to neurodegenerationSemantic proximity Read

Human IL-34 Deficiency Primes Microglia Toward Alzheimer’s Disease-Associated StatesSemantic proximity Read

STING–IFN–CH25H lipid axis links innate immune activation to tau pathologySemantic proximity Read

Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer’s Disease Revealed by Pharmacological and Genetic Microglial DepletionSemantic proximity Read

Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer's disease.Semantic proximity Read