Article
Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma.
Oncogene - 1 Oct 2020
Yang Risheng, Zhao Yuanlin, Gu Yu, Yang Ying, Gao Xing, Yuan Yuan, Xiao Liming, Zhang Jin, Sun Chao, Yang Han, Qin Junhui, Li Jing, Zhang Feng, Zhang Lijun, Ye Jing
Abstract excerpt
Isocitrate dehydrogenase (IDH) mutation is the most important initiating event in gliomagenesis, and the increasing evidence shows that IDH mutation is associated with the metabolic reprogramming in the tumor. Dysregulated cholesterol metabolism is a hallmark of tumor cells, but the cholesterol homeostasis in IDH-mutated glioma is still unknown. In this study, we found that astrocyte-specific mutant IDH1(R132H)...
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