Article

Triglyceride metabolism controls inflammation and <i>APOE4</i> -associated disease states in microglia

2024-04-13

Abstract excerpt

Microglia modulate their cell state in response to various stimuli. Changes to cellular lipids often accompany shifts in microglial cell state, but the functional significance of these metabolic changes remains poorly understood. In human induced pluripotent stem cell-derived microglia, we observed that both extrinsic activation (by lipopolysaccharide treatment) and intrinsic triggers (the Alzheimer’s disease-asso...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 87616570-d1b9-543a-8ffd-a20743f928d4
DOI: 10.1101/2024.04.11.589145

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Triglyceride metabolism controls inflammation and <i>APOE4</i> -associated disease states in microgliaDOI 10.1101/2024.04.11.589145Read

Impaired lipoprotein secretion by APOE4 leads to lysosomal and mitochondrial dysfunction in human microgliaSemantic proximity Read

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brainSemantic proximity Read

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microgliaSemantic proximity Read

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotypeSemantic proximity Read

ApoE Lipidation State Directs Immunometabolic Reprogramming of Human MicrogliaSemantic proximity Read

Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia.Semantic proximity Read

APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.Semantic proximity Read

<i>APOE</i> genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamicsSemantic proximity Read

Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation.Semantic proximity Read

Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s DiseaseSemantic proximity Read

Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer’s Disease Revealed by Pharmacological and Genetic Microglial DepletionSemantic proximity Read

Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network ActivitySemantic proximity Read