Article

25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation

2024-08-19

Abstract excerpt

<title>Abstract</title> <p>Neuroinflammation has been implicated in the pathogenesis of several neurologic and psychiatric disorders. Microglia are key drivers of neuroinflammation and in response to different inflammatory stimuli overexpress a proinflammatory signature of genes. Among these, <italic>Ch25h</italic> is a gene overexpressed in brain tissue from Alzheimer’s disease as well as various mouse models of...

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Literature Corpus work: 7ee6056c-4f95-5450-a2ee-027d9049b31b
DOI: 10.21203/rs.3.rs-4784189/v1

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