Article

Ch25h/25HC axis orchestrates phagocytosis and lipid metabolism after intracerebral haemorrhage

2026-02-20

Abstract excerpt

<title>Abstract</title> <p>Intracerebral haemorrhage (ICH) is a devastating form of stroke for which therapies are lacking. Secondary brain injury driven by erythrocyte lysis contributes to poor outcomes, highlighting the need to enhance endogenous haematoma clearance. Here, we identify cholesterol 25-hydroxylase (CH25H) and its product 25-hydroxycholesterol (25HC) as key regulators of phagocytic and lipid-handli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 908cf158-d6c7-5d23-bead-d5057e91422c
DOI: 10.21203/rs.3.rs-8845215/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ch25h/25HC axis orchestrates phagocytosis and lipid metabolism after intracerebral haemorrhageDOI 10.21203/rs.3.rs-8845215/v1Read

Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterolSemantic proximity Read

Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolutionSemantic proximity Read

Atherosclerotic plaque iron accumulation characterizes a distinct phase of intra-plaque haemorrhage and is associated with inflammation and remodellingSemantic proximity Read

Microglia-derived iron-overloaded exosomes induce neuronal ferroptosis and aggravate neurological impairment after subarachnoid hemorrhageSemantic proximity Read

Temporal and Age-Dependent Regulation of Phagocytosis-Related Signatures After Ischemic Stroke: Cross-Species Transcriptomic EvidenceSemantic proximity Read

Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage.Semantic proximity Read

HDL and cholesterol handling in the brain.Semantic proximity Read

Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in MacrophagesSemantic proximity Read

25-hydroxycholesterol mediates brain cytokine production and neutrophil infiltration in a mouse model of lipopolysaccharide-induced neuroinflammationSemantic proximity Read

25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammationSemantic proximity Read

Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma.Semantic proximity Read

Neuroinflammation in an optimized model of lysophosphatidic acid (LPA)-induced post-hemorrhagic hydrocephalusSemantic proximity Read