Article

Regulation of neuroinflammation by astrocyte-derived cholesterol

2022-12-13

Abstract excerpt

Neurodegeneration and its concomitant loss of cognitive function are closely linked to neuroinflammation and lipid accumulation, particularly cholesterol. In the brain, astrocytes synthesize cholesterol and deliver it to surrounding cells via apolipoprotein E (apoE). Astrocyte activation increases apoE secretion and promotes neuronal cell death, yet the link between astrocyte-derived cholesterol and inflammation r...

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Literature Corpus work: ed45f197-92db-58d4-9fac-4e468b3a942a
DOI: 10.1101/2022.12.12.520161

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