Article

U2af1S34F and U2af1Q157R myeloid neoplasm-associated hotspot mutations induce distinct hematopoietic phenotypes in mice

2025-05-07

Abstract excerpt

<title>Abstract</title> Recurrent somatic mutations in the spliceosome genes <italic>SF3B1</italic> , <italic>SRSF2</italic> , and <italic>U2AF1</italic> are frequently identified in patients with myeloid neoplasms, such as myelodysplastic syndromes. We characterized the <italic>in vivo</italic> consequences of expressing two hotspot mutations in <italic>U2AF1</italic> that code for the S34F and Q1...

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Literature Corpus work: dc6de71c-7264-5ef0-bd77-239e05be3e19
DOI: 10.21203/rs.3.rs-6377810/v1

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