Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

U2af1S34F and U2af1Q157R myeloid neoplasm-associated hotspot mutations induce distinct hematopoietic phenotypes in mice.

Leukemia - 1 Jul 2026

Alberti Michael O, Nonavinkere Srivatsan Sridhar, Shao Jin, Fei Dennis L, Zhu Mengou, Pastrana Claudia Cabrera, Chavez Monique, Tarnawsky Stefan P, Grieb Sarah, Graubert Timothy A, Abdel-Wahab Omar, Walter Matthew J

Abstract excerpt

Recurrent somatic mutations in the spliceosome genes SF3B1, SRSF2, and U2AF1 are frequently identified in patients with myeloid neoplasms, such as myelodysplastic syndromes. We characterized the in vivo consequences of expressing two hotspot mutations in U2AF1 that code for the S34F and Q157R substitutions. Our results indicate that the two mutations induce distinct hematopoietic phenotypes in mice, suggesting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to SF3B1 gene
Share to Hematopoiesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Myelodysplastic Syndromes

Share to Phenotype

Share to Serine-Arginine Splicing Factors

Share to Splicing Factor U2AF

Source

Open in PubMed Open full text

Identifiers

PMID: 42092046
DOI: 10.1038/s41375-026-02974-7
PMCID: PMC13276503

Genes

U2AF1
SF3B1
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

U2af1S34F and U2af1Q157R myeloid neoplasm-associated hotspot mutations induce distinct hematopoietic phenotypes in mice.PMID 42092046Read ↗

U2af1S34F and U2af1Q157R myeloid neoplasm-associated hotspot mutations induce distinct hematopoietic phenotypes in miceSemantic proximity Read ↗

Impaired hematopoiesis and leukemia development in mice with a conditional “knock-in” allele of a mutant splicing factor gene <i>U2af1</i>Semantic proximity Read ↗

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromesSemantic proximity Read ↗

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.Semantic proximity Read ↗

U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice.Semantic proximity Read ↗

<i>U2AF1</i> is a haplo-essential gene required for cancer cell survivalSemantic proximity Read ↗

The Biological and Clinical Consequences of RNA Splicing Factor U2AF1 Mutation in Myeloid MalignanciesSemantic proximity Read ↗

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1Semantic proximity Read ↗

Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia.Semantic proximity Read ↗

Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis.Semantic proximity Read ↗

Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical FeaturesSemantic proximity Read ↗

Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.