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Article

Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical Features

22 Nov 2019

Abstract excerpt

Components of the pre-messenger RNA splicing machinery are frequently mutated in myeloid malignancies. Mutations in LUC7L2, PRPF8, SF3B1, SRSF2, U2AF1, and ZRSR2 genes occur at various frequencies ranging between 40% and 85% in different subtypes of myelodysplastic syndrome (MDS) and 5% and 10% of acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs). In some instances, splicing factor (SF)...

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PMID: 31766606
DOI: 10.3390/cancers11121844

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