Article
U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice.
The Journal of clinical investigation - 1 Nov 2021
Wadugu Brian A, Nonavinkere Srivatsan Sridhar, Heard Amanda, Alberti Michael O, Ndonwi Matthew, Liu Jie, Grieb Sarah, Bradley Joseph, Shao Jin, Ahmed Tanzir, Shirai Cara L, Khanna Ajay, Fei Dennis L, Miller Christopher A, Graubert Timothy A, Walter Matthew J
Abstract excerpt
Somatic mutations in the spliceosome gene U2AF1 are common in patients with myelodysplastic syndromes. U2AF1 mutations that code for the most common amino acid substitutions are always heterozygous, and the retained WT allele is expressed, suggesting that mutant hematopoietic cells may require the residual WT allele to be viable. We show that hematopoiesis and RNA splicing in U2af1 heterozygous knockout mice were...
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