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Article

Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis.

Leukemia - 1 Oct 2023

Gurule Natalia J, Malcolm Kenneth C, Harris Chelsea, Knapp Jennifer R, O'Connor Brian P, McClendon Jazalle, Janssen William J, Lee Frank Fang Yao, Price Caitlin, Osaghae-Nosa Jackson, Wheeler Emily A, McMahon Christine M, Pietras Eric M, Pollyea Daniel A, Alper Scott

Abstract excerpt

Myelodysplastic neoplasm (MDS) is a hematopoietic stem cell disorder that may evolve into acute myeloid leukemia. Fatal infection is among the most common cause of death in MDS patients, likely due to myeloid cell cytopenia and dysfunction in these patients. Mutations in genes that encode components of the spliceosome represent the most common class of somatically acquired mutations in MDS patients. To determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37591942
DOI: 10.1038/s41375-023-02007-7
PMCID: PMC10539173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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