Article
[Hematological malignancies driven by aberrant splicing].
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2023
Zang Weijia, Saika Wataru, Aoyama Yumi, Inoue Daichi
Abstract excerpt
The process of RNA splicing plays a pivotal role in gene expression and genetic information modification by converting pre-mRNA into mature mRNA. Dysregulation of this process has been associated with aberrant gene expression and function, leading to hematopoietic malignancies. Through recent clinical and mouse model analyses, insights have been gained into the mechanisms underlying splicing factor mutations that...
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