Article
Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.
Cancer cell - 11 May 2015
Shirai Cara Lunn, Ley James N, White Brian S, Kim Sanghyun, Tibbitts Justin, Shao Jin, Ndonwi Matthew, Wadugu Brian, Duncavage Eric J, Okeyo-Owuor Theresa, Liu Tuoen, Griffith Malachi, McGrath Sean, Magrini Vincent, Fulton Robert S, Fronick Catrina, O'Laughlin Michelle, Graubert Timothy A, Walter Matthew J
Abstract excerpt
Heterozygous somatic mutations in the spliceosome gene U2AF1 occur in ∼ 11% of patients with myelodysplastic syndromes (MDS), the most common adult myeloid malignancy. It is unclear how these mutations contribute to disease. We examined in vivo hematopoietic consequences of the most common U2AF1 mutation using a doxycycline-inducible transgenic mouse model. Mice expressing mutant U2AF1(S34F) display altered...
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