Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes

23 Apr 2017

Abstract excerpt

Mutations of the splicing factor-encoding gene U2AF1 are frequent in the myelodysplastic syndromes (MDS), a myeloid malignancy, and other cancers. Patients with MDS suffer from peripheral blood cytopenias, including anemia, and an increasing percentage of bone marrow myeloblasts. We studied the impact of the common U2AF1S34F mutation on cellular function and mRNA splicing in the main cell lineages affected in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28436936
DOI: 10.1172/jci91363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromesPMID 28436936Read ↗

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.Semantic proximity Read ↗

U2af1 is required for survival and function of hematopoietic stem/progenitor cells.Semantic proximity Read ↗

The Biological and Clinical Consequences of RNA Splicing Factor U2AF1 Mutation in Myeloid MalignanciesSemantic proximity Read ↗

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.Semantic proximity Read ↗

U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing.Semantic proximity Read ↗

Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice.Semantic proximity Read ↗

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.Semantic proximity Read ↗

Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical FeaturesSemantic proximity Read ↗

Impaired hematopoiesis and leukemia development in mice with a conditional “knock-in” allele of a mutant splicing factor gene <i>U2af1</i>Semantic proximity Read ↗

RNA splicing as a therapeutic target in myelodysplastic syndromes.Semantic proximity Read ↗

Splicing factor mutations in the myelodysplastic syndromes: Role of key aberrantly spliced genes in disease pathophysiology and treatment.Semantic proximity Read ↗

Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.