Article

<i>U2AF1</i> mutations alter splice site recognition in hematological malignancies

2013-12-03

Abstract excerpt

Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3′ splice site recognition factor U2AF1 alter its normal role in RNA splicing. We find that U2AF1 mutations influence the similarity of splicing programs in leukemias, but do not give rise to widesp...

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Literature Corpus work: 78dd18f8-4e34-5588-bb44-4e9709d75e17
DOI: 10.1101/001107

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