Article

<i>U2AF1</i> is a haplo-essential gene required for cancer cell survival

2020-06-21

Abstract excerpt

Somatic mutations in the spliceosome gene U2AF1 are common in patients with myelodysplastic syndromes. U2AF1 mutations that code for the most common amino acid substitutions are always heterozygous, and the retained wild-type allele is expressed, suggesting that mutant hematopoietic cells may require the residual wild-type allele to be viable and cause disease. We show that hematopoiesis and RNA splicing in U2a...

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Literature Corpus work: 014d7d45-00c8-58ca-bdb7-53355a96f028
DOI: 10.1101/2020.06.20.151035

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