Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling

7 Mar 2019

Abstract excerpt

Genes encoding spliceosome components including SF3B1, U2AF1 , and SRSF2 , are frequently somatically mutated in myelodysplastic syndromes (MDS), other hematologic malignancies, and solid tumors.[1][1] Typically these are mutually exclusive, heterozygous, missense, hotspot mutations that result in

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Cancer-related gene regulation
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30846499
DOI: 10.3324/haematol.2018.214155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signalingPMID 30846499Read ↗

RNA splicing as a therapeutic target in myelodysplastic syndromes.Semantic proximity Read ↗

Spliceosome mutations in hematopoietic malignancies.Semantic proximity Read ↗

Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.Semantic proximity Read ↗

Splicing factor mutations in the myelodysplastic syndromes: Role of key aberrantly spliced genes in disease pathophysiology and treatment.Semantic proximity Read ↗

Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome.Semantic proximity Read ↗

Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes.Semantic proximity Read ↗

Targeting Aberrant Splicing in Myelodysplastic Syndromes: Biologic Rationale and Clinical Opportunity.Semantic proximity Read ↗

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.Semantic proximity Read ↗

Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes.Semantic proximity Read ↗

Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical FeaturesSemantic proximity Read ↗

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.Semantic proximity Read ↗

[Hematological malignancies driven by aberrant splicing].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.