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Impaired hematopoiesis and leukemia development in mice with a conditional “knock-in” allele of a mutant splicing factor gene U2af1

2018-06-12

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<h4>ABSTRACT</h4> Mutations affecting the spliceosomal protein U2AF1 are commonly found in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML). We have generated mice that carry Cre-dependent “knock-in” alleles of U2af1 (S34F), the murine version of the most common mutant allele of U2AF1 encountered in human cancers. Cre-mediated recombination in murine hematopoietic lineages caused chan...

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Literature Corpus work: 5ce06cb3-a42b-5221-ad08-e8a2811f33a3
DOI: 10.1101/345538

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Impaired hematopoiesis and leukemia development in mice with a conditional “knock-in” allele of a mutant splicing factor gene U2af1DOI 10.1101/345538Read

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Impaired hematopoiesis and leukemia development in mice with a conditional “knock-in” allele of a mutant splicing factor gene <i>U2af1</i>

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