Article

On the patterns of genetic intra-tumour heterogeneity before and after treatment

2024-10-13

Abstract excerpt

Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumulation and selection with important implications for the evolution of treatment resistance. Theoretical and data-driven approaches extensively studied gITH in ageing somatic tissues or cancers at detection. Yet, the expected patterns of gITH during and after treatment are...

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Literature Corpus work: dc677a31-bb7c-516f-afd6-403857b97454
DOI: 10.1101/2024.10.10.617575

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