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Measures of genetic diversification in somatic tissues at bulk and single cell resolution

2022-11-08

Abstract excerpt

Intra-tissue genetic heterogeneity is universal to both healthy and cancerous tissues. It emerges from the stochastic accumulation of somatic mutations throughout development and homeostasis. By combining population genetics theory and genomic information, genetic heterogeneity can be exploited to infer tissue organisation and dynamics in vivo . However, many basic quantities, for example the dynamics of tissue s...

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Literature Corpus work
71d22fdb-ed09-57b1-977b-fc6c6a5374d5
DOI
10.1101/2022.11.07.515470
Open publication

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Measures of genetic diversification in somatic tissues at bulk and single cell resolutionDOI 10.1101/2022.11.07.515470
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