Clonal Diversity at Early Cancer Recurrence.

Abstract excerpt

Despite initial success, cancer therapies often fail due to the emergence of drug-resistant cells. In this study, we use a mathematical model to investigate how cancer evolves over time, specifically focusing on the state of the tumor when it recurs after treatment. We use a two-type birth-death process to capture the dynamics of both drug-sensitive and drug-resistant cells. Assuming resistant cells have equal...

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