Article
Measuring single cell divisions in human cancers from multi-region sequencing data
2019-02-25
Abstract excerpt
Cancer is driven by complex evolutionary dynamics involving billions of cells. Increasing effort has been dedicated to sequence single tumour cells, but obtaining robust measurements remains challenging. Here we show that multi-region sequencing of bulk tumour samples contains quantitative information on single-cell divisions that is accessible if combined with evolutionary theory. Using high-throughput data from...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 252ca8e4-086e-5d18-8817-67f018ab34f9
- DOI
- 10.1101/560243