Article
Cell population heterogeneity and evolution towards drug resistance in cancer: Biological and mathematical assessment, theoretical treatment optimisation.
Biochimica et biophysica acta - 1 Nov 2016
Chisholm Rebecca H, Lorenzi Tommaso, Clairambault Jean
Abstract excerpt
BACKGROUND: Drug-induced drug resistance in cancer has been attributed to diverse biological mechanisms at the individual cell or cell population scale, relying on stochastically or epigenetically varying expression of phenotypes at the single cell level, and on the adaptability of tumours at the cell population level. SCOPE OF REVIEW: We focus on intra-tumour heterogeneity, namely between-cell variability within...
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