Article
The impact of phenotypic heterogeneity of tumour cells on treatment and relapse dynamics.
PLoS computational biology - 1 Feb 2021
Raatz Michael, Shah Saumil, Chitadze Guranda, Brüggemann Monika, Traulsen Arne
Abstract excerpt
Intratumour heterogeneity is increasingly recognized as a frequent problem for cancer treatment as it allows for the evolution of resistance against treatment. While cancer genotyping becomes more and more established and allows to determine the genetic heterogeneity, less is known about the phenotypic heterogeneity among cancer cells. We investigate how phenotypic differences can impact the efficiency of therapy...
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