On the patterns of genetic intra-tumor heterogeneity before and after treatment.

Abstract excerpt

Genetic intra-tumor heterogeneity is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumulation, and selection with important implications for the evolution of treatment resistance. Theoretical and data-driven approaches extensively studied intra-tumor heterogeneity in ageing somatic tissues or cancers at detection. Yet, the expected patterns of intra-tumor...

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