Eco-Evolutionary Dynamics of Proliferation Heterogeneity: A Phenotype-Structured Model for Tumor Growth and Treatment Response.

doi:10.1007/s11538-026-01740-1

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Eco-Evolutionary Dynamics of Proliferation Heterogeneity: A Phenotype-Structured Model for Tumor Growth and Treatment Response.

Bulletin of mathematical biology - 29 Aug 2026

Schmalenstroer Lara, Chen Haojun, Rockne Russell C, Farahpour Farnoush

Abstract excerpt

Intra-tumor heterogeneity in proliferation rates fundamentally influences cancer progression and treatment resistance. To investigate how continuous phenotypic variation shapes eco-evolutionary dynamics, we develop a phenotype-structured partial differential equation framework that explicitly models proliferation heterogeneity as a dynamic trait. Our model integrates three key biological principles: (1)...

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PMID: 42667491
DOI: 10.1007/s11538-026-01740-1
PMCID: PMC13526070

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