Single-cell mutational burden distributions in birth-death processes.

Abstract excerpt

Genetic mutations are footprints of cancer evolution and reveal critical dynamic parameters of tumour growth, which otherwise are hard to measure in vivo. The mutation accumulation in tumour cell populations has been described by various statistics, such as site frequency spectra (SFS), single-cell division distributions (DD) and mutational burden distributions (MBD). While DD and SFS have been intensively...

Topics

• Single-Cell Analysis
• Humans
• Neoplasms
• Mutation
• Computational Biology
• Models, Genetic
• Cell Division