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Article

Therapy-induced rapid drug resistance driven by genome chaos and polyploid giant cancer cells.

Cancer letters - 1 May 2026

Horne Steven D, Ye Jing Christine, Liu Guo, Abdallah Batoul Y, Stevens Joshua B, Heng Henry H

Abstract excerpt

Initially effective cancer drug treatments often lead to resistance with greater aggressiveness. Traditionally, this is attributed to preexisting mutation/epigenetic heterogeneity, which allow resistant populations to dominate through selection. The discovery of genome chaos-mediated rapid cellular macroevolution offers the new mechanism of drug resistance beyond pre-existing variants. To test the hypothesis that...

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PMID: 41763449
DOI: 10.1016/j.canlet.2026.218355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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