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PRDM16 controls smooth muscle cell fate in atherosclerosis

2025-02-23

Abstract excerpt

<h4>Summary</h4> Vascular smooth muscle cells (SMCs) normally exist in a contractile state but can undergo fate switching to produce various cell phenotypes in response to pathologic stimuli 1–3 . In atherosclerosis, these phenotypically modulated SMCs regulate plaque composition and influence the risk of major adverse cardiovascular events 4,5 . We found that PRDM16, a transcription factor that is genetically...

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Literature Corpus work
5946cade-cc5e-529b-bd38-b6336136fd5a
DOI
10.1101/2025.02.19.639186
Open publication

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PRDM16 controls smooth muscle cell fate in atherosclerosisDOI 10.1101/2025.02.19.639186
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